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Scientist, Oncology Bioscience
Location:
Waltham, MA
Description:
Scientist, Oncology BioscienceAre you a highly motivated Scientist with a strong scientific and technical expertise in oncology research? Do you have a track record of scientific excellence? If so, we have an exciting opportunity for you to join our Oncology R&D department in Waltham, MA USA. As a Scientist, you will be a key member of a team focused on supporting oncology projects through the drug discovery and development process. You will bring your theoretical and practical expertise in cancer biology to establish assay systems and deliver datasets that will have direct impact on targeted therapeutics.Accountabilities:In this role, you will work in a laboratory within the Oncology Research group designing, conducting and analyzing in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.Essential Skills/Experience: BS with 3+ years or MS with 1+ year experience in Biology, Oncology, Biochemistry, Pharmacology, Immunology or a related field Depth of understanding of solid tumor and hematology cancer models Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, Western blot, and cell death measurement in primary and cell line cultures) Experience conducting flow cytometry and visualizing/quantitating high content multi-parameter flow data Experience with multiple in-vitro tumor models (2D, 3D, organoid etc) Experience with genetic tools for cell line engineering (si/shRNA, CRISPR, transfection, transduction) Experience with cell biology and biochemical techniques to characterize cell signaling pathways (e.g. immunoprecipitation, immunofluorescence, luciferase activity, MSD/Luminex) Molecular biology skills including assessment of intracellular signaling and, generating and/or analyzing transcriptomic data Works equally well independently and in collaboration to execute assigned in a manner consistent with project goals. Reports data in a clear and concise manner, with a comprehensive understanding of its implications within the overall context of drug discovery. Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment. Desirable Skills/Experience: Prior experience in the biopharmaceutical industry preferable but not required. Familiarity with antibody drug conjugates or other targeted delivery modalities Familiarity with biology of tumor microenvironment (TME) and immunotherapy Knowledge of the drug discovery process and publications in credible scientific journals At AstraZeneca, we are committed to following the science. We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. We are pioneers, making bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We believe in growing together and providing a place where everyone can have a voice. We are ambitious and collaborative, optimistic in our ability to be resilient and work together towards a cure. We are diligent and committed to our science-driven approach, with a sharp focus on outcomes. We transform the way cancer is treated to make a meaningful difference to people and patients. Are you ready to make a difference? Apply today and join us in our mission to eliminate cancer as a cause of death! Date Posted 01-Jul-2024 Closing Date Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
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More About this Listing: Scientist, Oncology Bioscience
Scientist, Oncology Bioscience is a Science & Pharmaceutical Scientist Job at Astrazeneca located in Waltham MA. Find other listings like Scientist, Oncology Bioscience by searching Oodle for Science & Pharmaceutical Scientist Jobs.
Scientist, Oncology Bioscience is a Science & Pharmaceutical Scientist Job at Astrazeneca located in Waltham MA. Find other listings like Scientist, Oncology Bioscience by searching Oodle for Science & Pharmaceutical Scientist Jobs.